Inside Lupus: The Potential of Genetic Endotypes to Personalize Lupus Care

In this episode of the Lupus Science and Medicine Podcast, host Dr. Anna Wolska speaks with Dr. Amerie Grammer about how genetic breakthroughs are paving the way for personalized lupus care. Researchers have identified distinct “genetic endotypes,” patterns of gene activity that explain why lupus affects people differently, including symptoms like kidney disease. These insights could one day enable more precise, targeted treatments. Tune in as we unpack what genetic endotypes are, what they reveal about lupus, and how this research brings us closer to truly individualized care for everyone living with the disease.

 

Read the paper published in LSM: https://doi.org/10.1136/lupus-2025-001526